Calcium supplements so you can Phosphorus Proportion, PTH, and you can Bone Health

Kemi VE, Karkkainen MU, Karp HJ, Laitinen KA, Lamberg-Allardt CJ

Prices of the Ray Peat, PhD: “The fresh proportion out-of calcium in order to phosphate is very important; that’s why dairy and you can cheese are rewarding for weight loss, or for stopping weight gain. For many who are not extremely productive, reduced fat dairy and you may cheddar are more effective, as excess fat fat are not requisite.”

“The meals highest from inside the phosphate, in line with calcium, try grain, beans, meat, and you will seafood. Of numerous prepared dishes have additional phosphate. Products having a high, safe ratio out of calcium to phosphate was leaves, including kale, turnip veggies, and you can beet greens, and lots of fresh fruit, milk, and you will parmesan cheese.”

Br escort in Pomona J Nutr

“Free unsaturated fatty acids activate the stress hormonal, and you will cortisol reduces oxidization away from glucose and you will transforms it into the oily acids and triglycerides. Staying cortisol and you may stress reduced ‘s the fundamental question. Staying a top ratio off calcium supplements so you can phosphate really helps to contradict the pressure metabolic process.” “Present publication try indicating that continuously phosphate increases soreness, tissue atrophy, calcification regarding arteries, malignant tumors, dementia, and you can, generally, the latest process away from aging.”

2006 September;96(3):545-52. Large phosphorus intakes exceedingly and you may negatively apply at California and you may bones kcalorie burning into the a dosage-centered manner inside compliment younger ladies. Kemi VE, Karkkainen MU, Lamberg-Allardt CJ. California and you can P is each other essential nutrients to have limbs and tend to be proven to apply at probably one of the most very important bodies from bone kcalorie burning, parathyroid hormones (PTH). As well nice an effective P consumption, normal from West diet, will be deleterious so you’re able to bones from the improved PTH secretion. Few controlled amount-reaction studies are available on the results regarding high P consumption for the child. I analyzed the new short-label aftereffects of five P dosage with the Ca and you will bone metabolic process into the fourteen compliment ladies, 20-twenty eight yrs . old, have been randomized to help you five managed analysis days; hence for every single studies topic supported since the her own manage. P complement amounts regarding 0 (placebo), 250, 750 or 1500 mg have been pulled, divided into three dosage in the research day. The dishes served up had been exactly the same through the per data time and you can provided 495 mg P and you may 250 mg California. The fresh P dosage affected the brand new serum PTH (S-PTH) inside the a dose-built manner (P=0.0005). There is a reduction in serum ionized California amount only in the best P serving (P=0.004). This new marker off bone development, bone-particular alkaline phosphatase, reduced (P=0.05) in addition to bone resorption marker, N-terminal telopeptide away from collagen method of We, improved as a result towards the P amounts (P=0.05). That it managed dose-effect analysis revealed that P keeps a serving-depending impact on S-PTH and you can expands PTH secretion somewhat whenever California consumption are low. Excessively large P consumption adversely affects bones metabolic process by decreasing limbs development and you may expanding bone resorption, because the conveyed of the bone metabolic process markers.

20 Oct 1. Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females. A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is too low. This combination may not be optimal for bone health. In a previous controlled study, we found that dietary P dose-dependently increased S-PTH and bone resorption and decreased bone formation. The aim of the present study was to investigate the dose-response effects of Ca intake on Ca and bone metabolism with a dietary P intake higher than recommended. Each of the twelve healthy female subjects aged 21-40 years attended three 24-h study sessions, which were randomized with regard to a Ca dose of 0 (control day), 600 or 1200 mg, and each subject served as her own control. The meals on each study day provided 1850 mg P and 480 mg Ca. S-PTH concentration decreased (P < 0.001) and serum ionized Ca concentration increased (P < 0.001) with increasing Ca doses. The bone formation marker, serum bone-specific alkaline phosphatase, did not differ significantly (P = 0.4). By contrast, the bone resorption marker, urinary N-terminal telopeptide of collagen type I, decreased significantly with both Ca doses (P = 0.008). When P intake was above current recommendations, increased Ca intake was beneficial for bone, as indicated by decreased S-PTH concentration and bone resorption. However, not even a high Ca intake could affect bone formation when P intake was excessive.